Saturday, February 2, 2013

Alaska Airlines pilot passes out midair, co-pilot lands plane

SEATTLE (Reuters) - A Seattle-bound Alaska Airlines flight made an emergency landing in Oregon after its veteran pilot passed out in the passenger cabin, in the second such fainting spell involving the U.S. carrier in 10 days, the airline said on Friday.

Flight crew and passengers helped revive the pilot and guide him into a vacant passenger seat while the co-pilot took control of the Boeing 737-700 and safely landed in Portland late on Thursday, airline spokesman Paul McElroy said.

"Doctors suspect he became ill due to food-poisoning or the flu virus," McElroy said of the pilot, a 28-year aviation veteran, adding that none of the 116 passengers and five crew members on board the flight from Los Angeles were injured.

The pilot was hospitalized in Portland, and McElroy said the two fainting episodes were a "bizarre coincidence."

Federal Aviation Administration spokesman Ian Gregor said investigators did not immediately see a connection between the incident and a similar situation on January 22 in which an Alaska Airlines co-pilot fainted on a flight between Seattle and Las Vegas, forcing the captain to make an emergency landing.

"That first officer was infected with the flu. We know that for sure," McElroy said.

(Reporting by Laura L. Myers, writing by Eric M. Johnson; editing by Cynthia Johnston, G Crosse)

Source: http://news.yahoo.com/alaska-airlines-pilot-passes-midair-co-pilot-lands-181551055--finance.html

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Engineered oncolytic herpes virus inhibits ovarian and breast cancer metastases

Friday, February 1, 2013

A genetically reprogrammed Herpes simplex virus (HSV) can cure metastatic diffusion of human cancer cells in the abdomen of laboratory mice, according to a new study published January 31 in the Open Access journal PLOS Pathogens. The paper reports on the collaborative research from scientists at the at the University of Bologna and specifically describes that the HSV converted into a therapeutic anticancer agent attacks breast and ovarian cancer metastases.

Past decades have witnessed significant progress in the ability to treat numerous cancers by means of surgery, chemo- and radio-therapy, or combinations thereof. However, many treatments prolong life for a short time only, or are associated with a poor quality of life.

Lead investigator Gabriella Campadelli-Fiume and colleagues re-engineered the entry apparatus of a candidate oncolytic herpesvirus. The reprogrammed virus no longer infects the cells usually targeted by the wild-type virus, nor does it cause herpes-related pathologies. Rather, it acts as a specific weapon against tumor cells that express the HER-2 oncogene.

"Numerous laboratories worldwide are using viruses as more specific weapons against cancer cells, called oncolytic viruses", says Campadelli-Fiume, Professor of Microbiology and Virology. "Safety concerns prevailed so far, and all oncolytic herpesviruses now in clinical trials are debilitated viruses, effective only against a fraction of tumors. We were the first to obtain a herpes virus reprogrammed to enter HER-2-positive tumor cells, unable to infect any other cell, yet preserves the full-blown killing capacity of the wild-type HSV".

Additionally, the laboratory of Pier-Luigi Lollini, Patrizia Nanni and Carla De Giovanni in collaboration with researchers at the Rizzoli Institute, established the new model of human cancer metastases in mice that was used to demonstrate the therapeutic efficacy of the reprogrammed virus.

The positive results obtained in the treatment of experimental metastasis hold the promise that the newly retargeted oncolytic HSV described in PLOS Pathogens is a good candidate to become a novel type of cancer treatment, and represents a key step forward in the path to clinical trials for late stage human breast and ovarian cancers.

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Public Library of Science: http://www.plos.org

Thanks to Public Library of Science for this article.

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Source: http://www.labspaces.net/126587/Engineered_oncolytic_herpes_virus_inhibits_ovarian_and_breast_cancer_metastases

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Film Review: 'Midnight's Children' | Mumbai Boss

Satya Bhabha and Siddharth as Saleem Sinai and Shiva.

Director:?Deepa Mehta
Cast:?Satya Bhabha, Ronit Roy, Shahana Goswami, Seema Biswas, Rajat Kapoor, Siddharth, Shriya Saran, Darsheel Safary, Shabana Azmi, Rahul Bose
Rating: ?????

At a recent event to promote Deepa Mehta?s adaptation of Salman Rushdie?s Midnight?s Children, the film?s producer David Hamilton said that fans of the book were likely to have their own cinematic versions playing in their heads, each incomparable to the other. It?s that sort of novel. Perhaps these films should never be allowed to leave cranial walls as Midnight?s Children, to use an arboreal comparison, is like a lush banyan tree?its narrative branches off into scores of delightful digressions and mini stories that would be impossible to fit into a movie of watchable length. However the?Midnight?s Children?to emerge from Mehta?s attractive salt and pepper head?and Rushdie?s ruddy, bald one as he wrote the screenplay?is like a tree in winter. The film is a clipped rendition that races to cover a period that spans pre-Independence India and the end of the Emergency in two and a half hours and in the process minimises characters and crucial events.

The only character you get a sense of is Saleem Sinai (Satya Bhabha). Born on the midnight of Independence, Saleem and his fellow midnight?s children, all of whom have special powers, embody the promise of a new India. (Scenes in which the kids telepathically meet seem like an Indian version of X-Men.) But Saleem is hardly given a chance to fulfill the promise because events beyond his control take charge of his life the moment he?s born. The illegitimate child of a minstrel and a Brit on his way out of the country (Charles Dance), Saleem is swapped at birth with Shiva by nurse Mary (Seema Biswas, who delivers the best performance in the film), who in a misguided tribute to her communist lover Joe decides that the boy born to a poor woman must lead a life of comfort and the boy born to rich parents a life of poverty.

And so Saleem is brought up by the affluent Sinais while Shiva grows up as an angry tough guy on the streets of Bombay. Life casts Saleem among Pakistani generals, erases his memory with a flying spittoon, air drops him into Bangladesh during the 1971 war and repatriates him to India in a magic basket. On the other hand little is shown of Saleem?s antithesis, Shiva, a fantastic character who is only shown as a pugnacious boy and a stony-faced Aviator-wearing military hero (Siddharth). Saleem?s love interest and midnight?s child Parvati (Shriya Saran) too is unsatisfactorily etched. Saran turns Parvati, a magician living in a colony of entertainers in Delhi that Mehta imbues with a perplexing exoticism, into a simpering, eyelid-batting flirt with little emotional weight.

A large part of the novel?s appeal lies in Rushdie?s ability to conjure the bizarre and magic realism with wit and incredibly evocative language. Mehta?s film is leached of humour and strangeness and the magic real bits are often ridiculous. In a Harry Potter-esque moment, the day-time sky darkens ominously when Indira Gandhi announces the Emergency and Picture Singh (Kulbhushan Kharbanda), a turbaned patriarch in the colony of entertainers, gazes upwards and gutturally declares, ?Curse is upon us?. Rushdie tries to compensate by way of a voice-over?he delivers it himself?that draws from the language of the novel. But it?s simply not enough.

Tags: Charles Dance, David Hamilton, Deepa Mehta, Kulbhushan Kharbanda, Salman Rushdie, Satya Bhabha, Seema Biswas, Shriya Saran, Siddharth

Source: http://mumbaiboss.com/2013/02/01/film-review-midnights-children/

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Friday, February 1, 2013

The future of strategic planning | Atlas Corps

Strategic Planning Wordle

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During my entire career I have been a restless advocate for Strategic Planning as a tool to help organizations to get prepared for the future, anticipate and manage changes.

As a young management consultant, I had the chance to work with one of the most prestigious strategy firms to support Fortune 100 companies to plan their future and as a social sector professional, I worked tireless to advise more than 20 innovative social entrepreneurs to clarify their mission and vision.

All this experiences were indescribable valuable and undoubtedly the strategic planning process was extremely beneficial to all those organizations. However, when I ?look back it is not hard to recognize that most of the strategic planning documents that I helped to write few years ago led those organizations to very different and unpredictable directions.

exponential?I believe it is not too drastic to affirm that the traditional strategic plan model is obsolete. The world is changing very fast, for centuries we have been living in a linear world with continuous growth with very little if any change, like in a straight line but we now living in world of exponential changes. Economists like Chris Martenson, believe that the coming 20 years are going to look completely unlike the last 20 years.

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So, how to plan the future in a scenario of dynamic changes where the future is no longer reasonably predictable based on the past, communication is fast and efficient and data is more and more accessible?

I recently read this very insightful?article?at the Stanford Social Innovation Review blog that is very worth sharing:

In today?s fast-changing world, why freeze your strategic thinking in a five-year plan?

Take a moment and read these two words: strategic plan. Now close your eyes and picture one. If what comes up is a thick binder, gathering dust on a shelf next to other thick binders from five and ten years past, you?re not alone. We believe that a better understanding of the history of strategy and what caused the demise of binder-bound strategic planning can point the way to re-inventing strategy for the world we live in today. It is important to remember that strategy?s roots are military. Military strategy focuses on setting objectives, collecting intelligence, and then using that intelligence to make informed decisions about how to achieve your objectives?take that hill, cut this supply line.

Historically, the battlefield was a place where you could count on a few constants:

  • The past was a good predictor of the future. There were years or decades between meaningful shifts in the basic variables, such as the power of a soldier?s weapons or the range of aircraft.
  • Good data was scarce and hard to come by. Scouts and spies had to risk their lives to find and relay information, and had to be ever on the lookout for enemy deception.
  • Lines of communication were unreliable at best. Small numbers of clear directives were a tactical imperative.

Not surprisingly, after a couple of millennia, military strategy became well adapted to these constraints.

After World War II, when military strategy came into the business world as strategic planning, so did these constraints. As a result, strategic planners focused on predicting the future based on historic trend lines; invested heavily in gathering all available data; and produced a small number of directives issued from the top, for the rest of the organization to execute.

This approach to strategic planning was a reasonably good fit for much of the business world from the fifties through the eighties. But with the rise of high-tech tools and increased globalization in the nineties, the world began to change, and now it looks quite different indeed. The future is no longer reasonably predictable based on the past?in fact, it is liable to be startlingly different. Good data is easy to access and cheap to acquire. Communication is rapid, indiscriminate, and constant.

The world has become a more turbulent place, where anyone with a new idea can put it into action before you can say ?startup? and launch widespread movements with a single Tweet. This has left organizational leaders with a real problem, since the trusted, traditional approach to strategic planning is based on assumptions that no longer hold. The static strategic plan is dead.

This has led to increasingly polarized attitudes about the value of having a strategy at all. Some leaders are valiantly trying to save strategic planning by urging us to focus even more on rigorous data analysis. Others deny the value of strategy, arguing that organizations need agility above all else (an attitude that famed strategist Roger Martin?reports hearing with increasing frequency).

We think that what is necessary today is a strategy that breaks free of static plans to be adaptive and directive, that emphasizes learning and control, and that reclaims the value of strategic thinking for the world that now surrounds us. Martin acknowledged this point at the Skoll World Forum in 2010 when he said: ?Every model is wrong and every strategy is wrong. Strategy in a way helps you learn what is ?righter?. People think you can prove a strategy in advance. You can?t.?

The approach we developed in working with our clients at Monitor Institute is what we call?adaptive strategy. We create a roadmap of the terrain that lies before an organization and develop a set of navigational tools, realizing that there will be many different options for reaching the destination. If necessary, the destination itself may shift based on what we learn along the way.

Creating strategies that are truly adaptive requires that we give up on many long-held assumptions. As the complexity of our physical and social systems make the world more unpredictable, we have to abandon our focus on predictions and shift into rapid prototyping and experimentation so that we learn quickly about what actually works. With data now ubiquitous, we have to give up our claim to expertise in data collection and move into pattern recognition so that we know what data is worth our attention. We also know that simple directives from the top are frequently neither necessary nor helpful. We instead find ways to delegate authority, get information directly from the front lines, and make decisions based on a real-time understanding of what?s happening on the ground. Instead of the old approach of ?making a plan and sticking to it,? which led to centralized strategic planning around fixed time horizons, we believe in ?setting a direction and testing to it,? treating the whole organization as a team that is experimenting its way to success.

This approach wouldn?t surprise anyone in the world of current military strategy. Recent generations of military thinkers have long since moved beyond the traditional approach, most notably famed fighter pilot John Boyd. He saw strategy as a continuous mental loop that ran from?observe?to?orient?to?decide?and finally to?act, returning immediately to further observation. By adopting his mindset (with a particular emphasis on the two O?s, given our turbulent context), we can get much better at making strategy a self-correcting series of intentional experiments.

To provide structure to this fluid approach, we focus on answering a series of four interrelated questions about the organization?s strategic direction: what vision you want to pursue, how you will make a difference, how you will succeed, and what capabilities it will take to get there.

The skills and mindset for today?s strategic planning will come from continuously asking ourselves these questions about our organizations, programs, and initiatives. Once we accept Dwight D. Eisenhower?s sage advice that ?Plans are useless, but planning is everything,? we will be ready to adapt to whatever curveballs the twenty-first century sees fit to throw.

Source: http://www.atlascorps.org/blog/?p=1663

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Exercise Responsibly: Avoid Sensorineural Hearing Loss | Hearing ...

Whether you?re a dedicated fitness buff or someone who?s just beginning to get back into shape, congratulations. Research suggests regular exercise is good for our overall health ? including our hearing health. However, exercising beyond your fitness level or in classes where the music is playing too loud can lead to sensorineural hearing loss, a permanent condition that is easily avoided by taking a few precautions.

The first thing you should do before beginning an exercise program is check with your doctor to determine whether you?re healthy enough to participate. Once you?ve received the go-ahead, take action to protect your hearing with the following tips:

1. Don?t exercise beyond your fitness level. Be sure to warm up properly, pace yourself and take breaks when necessary. Sudden hearing loss can occur when you exercise too hard. Symptoms include dizziness, a feeling of fullness in the ears and tinnitus (ringing in the ears).

Your hearing should return to normal after a few hours; however, if you notice this happens on an on-going basis, see your doctor. You may have an abnormality such as a perilymphatic fistula, a genetic defect of the inner ear such as Large Vestibular Aqueduct Syndrome (LVAS) or another inner ear disorder such as Meniere?s disease.

2. If the music is too loud, ask the instructor to turn it down. If you have to shout to be heard at arm?s length, then the music in your fitness class is probably too loud. Researchers from George Mason University measured the sound levels in spinning classes through out the United States and found they measured between 100-110 decibels (dB), which is 30-40 dB above the maximum levels recommended by the American Council on Exercise (ACE).

If the instructor won?t turn down the volume, move away from the speakers, wear inexpensive foam ear plugs (available at your local drugstore) ? or find another fitness class where the instructor is more concerned about your hearing health.

3. Ditto for the volume in your headphones, too. Listening to music at a high volume through headphones can also cause sensorineural hearing loss. The National Institute on Deafness and other Communication Disorders (NIDCD) estimates 15 percent of Americans between the ages of 20 and 69 have high frequency hearing loss that may have been caused by exposure to loud noise on the job or through leisure activities. For reference, prolonged exposure to noise above 85 decibels (dB) can damage your hearing permanently. It?s okay to use music to motivate you during your exercise routine, just make sure it?s not so loud it defeats the purpose of contributing to your overall good health.

Article source: http://www.healthyhearing.com/content/articles/Hearing-loss/Protection/50997-Exercise-responsibly-avoid-sensorineural-hearing-loss

Source: http://www.hearing-aid-news.com/exercise-responsibly-avoid-sensorineural-hearing-loss/

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Outdoor fast food ads could promote obesity

Jan. 30, 2013 ? Past studies have suggested a relationship between neighborhood characteristics and obesity, as well as a connection between obesity and advertisements on television and in magazines.

Now, new research from UCLA has identified a possible link between outdoor food ads and a tendency to pack on pounds. The findings, researchers say, are not encouraging.

In a study published online in the peer-reviewed journal BMC Public Health, Dr. Lenard Lesser and his colleagues suggest that the more outdoor advertisements promoting fast food and soft drinks there are in a given census tract, the higher the likelihood that the area's residents are overweight.

"Obesity is a significant health problem, so we need to know the factors that contribute to the overeating of processed food," said Lesser, who conducted the research while a Robert Wood Johnson Foundation Clinical Scholar at the UCLA Department of Family Medicine and UCLA's Fielding School of Public Health.

"Previous research has found that fast food ads are more prevalent in low-income, minority areas, and laboratory studies have shown that marketing gets people to eat more," said Lesser, now a research physician at the Palo Alto Medical Foundation Research Institute in California. "This is one of the first studies to suggest an association between outdoor advertising and obesity."

For the study, the researchers looked at two densely populated areas in Los Angeles and New Orleans, each with more than 2,000 people per square mile. They focused on more than 200 randomly selected census tracts from those two areas, which included a mixture of high- and low-income residents.

The team used data on outdoor food advertising in those areas gleaned from a previous study on ads and alcohol consumption (which had tracked all the outdoor ads). They then linked that information with telephone-survey data from the same study, in which nearly 2,600 people between the ages of 18 and 98 from those areas were asked health-related questions in addition to questions about their height, weight, self-reported body mass index (BMI) and soda consumption.

The researchers found a correlation: The higher the percentage of outdoor ads for food, the higher the odds of obesity in those areas.

"For instance, in a typical census tract with about 5,000 people, if 30 percent of the outdoor ads were devoted to food, we would expect to find an additional 100 to 150 people who are obese, compared with a census tract without any food ads," Lesser said.

Given that the study focused on only two areas, the authors urge further research to determine if the findings would be replicated in other areas. Because the study was cross-sectional, the researchers do not claim that the ads caused the obesity. They also note that self-reported information about weight is subject to recall bias, and people often under-report their true weight.

But this study suggests enough of a link between outdoor food advertising and "a modest, but clinically meaningful, increased likelihood of obesity" to warrant further examination, the researchers conclude.

"If the ... associations are confirmed by additional research, policy approaches may be important to reduce the amount of food advertising in urban areas," the researchers write, while noting that outright bans on such ads might be deemed unconstitutional. "Innovative strategies, such as warning labels, counter-advertising, or a tax on obesogenic advertising should be tested as possible public health interventions for reducing the prevalence of obesity."

Frederick J. Zimmerman of UCLA and Deborah A. Cohen of the RAND Corp. co-authored this study, which was funded by the Robert Wood Johnson Foundation Clinical Scholars program.

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Story Source:

The above story is reprinted from materials provided by University of California, Los Angeles (UCLA). The original article was written by Enrique Rivero.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Lenard I Lesser, Frederick J Zimmerman, Deborah A Cohen. Outdoor advertising, obesity, and soda consumption: a cross-sectional study. BMC Public Health, 2013; 13 (1): 20 DOI: 10.1186/1471-2458-13-20

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/LMH33gt3od8/130131083803.htm

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Facebook introduces 'a new type of gift card,' is a lot like the old types

Facebook introduces 'a new type of gift card', is a lot like the old types

If you're still desperate to get that Facebook acquaintance something for their birthday or some kind of anniversary, the Social Network has instituted a new way to take your money give. You'll be able to pick up gift credit for the likes of Jamba Juice, Olive Garden, Sephora and Target, plucking what you'd like from the "gift cards and digital" category inside the existing Gifts tab, and stating an amount and the name of the lucky gift-getter. The friend will be immediately notified and a lovingly Facebook-branded card will be sent to their residence. The credit can be used immediately, reused and even hold multiple balances for the differing providers -- ideal for the times you need fragrances, electronics and ... olives. Balances can be monitored direct from your Facebook page or app, even updating and sending notifications when credit is being used. Facebook says the cards will roll-out gradually across the US, though wasn't specific on any launch regions. Expect to hear more in the next few days.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/9MXkuqPGgcY/

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