By Harichandan Arakali | BANGALORE (Reuters) ? Indian IT outsourcing company Zensar Technologies is looking to spend up to $60 million on an acquisition this year to boost its presence in the United States, chief financial officer S. Balasubramaniam ?
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FILE - This Oct. 22, 2007, file photo shows the general hospital, behind some tourists on the south side of Ellis Island in the New York harbor. The National Trust for Historic Preservation announces its 2012 list of the 11 most endangered historic places. This year?s list includes historic U.S. Post Office buildings nationwide, the historic Atlanta district where Martin Luther King Jr. was born, the boyhood home of Malcolm X in Boston, the hospital complex at Ellis Island in New York Harbor, and the courthouses of Texas, among others. (AP Photo/Seth Wenig, File)
FILE - This Oct. 22, 2007, file photo shows the general hospital, behind some tourists on the south side of Ellis Island in the New York harbor. The National Trust for Historic Preservation announces its 2012 list of the 11 most endangered historic places. This year?s list includes historic U.S. Post Office buildings nationwide, the historic Atlanta district where Martin Luther King Jr. was born, the boyhood home of Malcolm X in Boston, the hospital complex at Ellis Island in New York Harbor, and the courthouses of Texas, among others. (AP Photo/Seth Wenig, File)
FILE - This May 8, 2009, file photo shows Ellis Island's boarded up hospital for contagious disease ward, which opened in 1909 as part of the island's main hospital complex. The National Trust for Historic Preservation has released its annual list of America's 11 Most Endangered Historic places. In the past 25 years, the non-profit organization has listed 234 sites. New York State has made the list 18 times. This section of Ellis Island, where 29 neglected hospital and support buildings are located, has been cited three times, including this year. (AP Photo/Bebeto Matthews, File)
WASHINGTON (AP) ? Hundreds of historic U.S. post offices nationwide face uncertain futures as the U.S. Postal Service downsizes, so preservationists on Wednesday added these American institutions to the list of the country's most endangered historic places.
Post offices will join the list of America's 11 Most Endangered Historic Places as a group for the first time. The National Trust for Historic Preservation is citing the bureaucratic process for disposing of thousands of post offices, saying developers and community groups interested in rehabilitating the historic buildings end up walking away when they don't get timely or clear answers from the Postal Service.
The group also said New York's Ellis Island hospital complex is threatened, even though it's a popular historic destination, because the facility where thousands of immigrants received medical treatment upon their arrival has been left open to the elements.
Princeton Battlefield, the site of a pivotal American Revolution episode in New Jersey, also is facing imminent danger from housing development that would change the landscape, preservationists said.
This is the 25th anniversary of the listing of endangered places. Over that time 242 historic sites have been added to the listing. Only 10 sites of those have been lost, while others are still endangered, officials said.
The nation's post offices represent the largest number of sites that could be lost in towns and cities both large and small. Preservationists began getting calls more than a year ago about individual post offices, so they want to work with the Postal Service to help foster a process for adapting and reusing the historic buildings, said Stephanie Meeks, president of the National Trust for Historic Preservation.
"This isn't about taking on the post office," she said. "Of course we don't quibble with the post office having to do what they have to do to manage their business, but we do want to make sure there's a thoughtful process in place for managing the historic resources."
One developer in Geneva, Ill., walked away from negotiations with the Postal Service after months of work, citing a lack of clear answers from the agency.
The Postal Service on Wednesday said its plans have changed for many post offices since a study last summer. As of May 2012, the agency plans to consolidate about 460 mail processing centers in phases.
Of more than 31,500 post offices nationwide, only 55 are officially listed on the National Register of Historic Places, agency spokeswoman Sue Brennan said. If the Postal Service seeks to sell any historic property, Brennan said the agency follows State Historic Preservation Office guidelines to identify historic elements that must be saved.
Another large group of sites being added to the endangered list includes the courthouses of Texas, with support from former first lady Laura Bush. The state's courthouses were first listed in 1998, but at least 70 of them still need critical repairs. Most are still in use.
Other sites are facing even more imminent threats.
President Theodore Roosevelt's Elkhorn Ranch in North Dakota's Badlands, which inspired his views on conservation, is facing development of a road and bridge project that would "mar" the landscape and "stain Roosevelt's legacy of conservation," the group said.
Three sites from black history also are being added to the list: Joe Frazier's gym in Philadelphia where he trained to take on Muhammad Ali, the boyhood home of Malcolm X in Boston and Atlanta's Sweet Auburn Historic District, where Martin Luther King Jr. was born and later preached.
This is the second time that Sweet Auburn has been among the most endangered sites. It was first listed in 1992 when the area around King's birth home was at risk. Since then, much of the area has been revitalized, but much of the commercial corridor remains vacant and could be wiped out by new development, said Mtamanika Youngblood, president of the neighborhood's Sustainable Neighborhood Development Strategies Inc.
"We fear that if we lose any more ... we will lose the essence of Sweet Auburn," she said, noting that the historic Atlanta Daily World Building and Atlanta Life Insurance Buildings stand vacant, along with the original Southern Christian Leadership Conference Building and others.
In practical terms, the area could also lose its historic district status if its commercial corridor disappears, she said.
"If this place is important enough for people to come halfway around the world to visit ... there should be some civic will," Youngblood said.
Federal and local officials do hope a coming $94 million streetcar project linking the Auburn Avenue district with downtown and the tourist hot spots will attract businesses to a long-depressed economic area.
Diverse communities are often underrepresented in the preservation of cultural resources. Only 3 percent of the sites listed on the National Register of Historic Places represent diverse communities, Meeks said.
___
National trust for Historic Preservation: http://www.preservationnation.org/
___
Follow Brett Zongker on Twitter at: https://twitter.com/DCArtBeat
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A new study suggests that protein knots, a structure whose formation remains a mystery, may have specific functional advantages that depend on the nature of the protein's architecture.
"The presence of a knotted or slipknotted structure in a protein is relatively rare but really is very interesting," said Kenneth Millett, a professor of mathematics at UC Santa Barbara and a co-author of the paper, "Conservation of complex knotting and slipknotting patterns in proteins," published in the Proceedings of the National Academy of Sciences.
Relatively little is known about protein folding, the process by which a polypeptide chain with a specific sequence of amino acid chains forms the three-dimensional structures ?? their "native states" ?? required to become functional. How this process reproducibly achieves the required structure is the subject of intensive study. Even harder is understanding how this is accomplished for knotted proteins, where the chain loops around itself in entanglements of varying complexity; or the even rarer slipknotted proteins, where a loop is bound by another segment of the protein chain, similar to a shoelace bow.
What intrigued the scientists about the protein knots is that the folding process resulting in the formation of knots is intrinsically more difficult than the process producing unknotted proteins. The protein has to avoid not only energetic traps but also topological barriers. If an amino acid chain takes too much time to find its native state or if it is stuck in a misfolded or partially unfolded state, the result may be a useless protein or one that produces harm by causing protein aggregation which is known to cause neurodegenerative disorders.
"From an evolutionary point of view, knotting might seem unlikely to occur but, in fact, it does occur," said Millett, who, along with co-first authors Joanna Sulkowska from UC San Diego and Eric J. Rawdon from the University of Saint Thomas and with Jose N. Onuchic from Rice University and Andrzej Stasiak from the University of Lausanne, examined, analyzed, and classified 74,223 protein structures submitted to the Protein Data Bank for the location and formation of knots. Millett worked on the development of the mathematical theory and the computer implementation needed to identify the location and type of knots in the proteins studied in the paper.
What they found was that protein knots and slipknots, instead of being discarded through the process of evolution, are often strongly conserved. This suggests that, despite their reduced efficiency of folding, the knots are somehow advantageous and important to the function of the protein.
Additionally, the researchers found that the location of these knots and slipknots is highly conserved, marked by points of flexibility ?? "hinges" ?? in the chain that may have properties necessary for more efficient folding.
Knots and slipknots could contribute to the stability of the protein, as shown by the similar slipknot loops observed in several families of proteins that form transmembrane channels ?? the ducts through membranes of a cell, that allow certain materials to pass through. The slipknot, according to the authors, seems to strap together several transmembrane structures giving stability and forming the channel needed to allow passage through cell membranes.
The researchers will continue their study of the little-understood process of protein folding and knotting, said Millett.
"These knots may help to identify features that turn out to be important, and aspects of the structure that are more generalizable. We need to clearly understand how these things come to be, what are the implications of their structure, and how might one be able to somehow guide them," said Millett.
###
University of California - Santa Barbara: http://www.ucsb.edu
Thanks to University of California - Santa Barbara for this article.
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