Sunday, December 23, 2012

Mayan apocalypse failure bad news for believers

You might expect the world not ending to be a cause for celebration. But for believers in doomsdays like Friday's supposed Mayan apocalypse, the continued existence of the planet can be quite traumatic.

Friday was widely rumored online to be the end of the world, a misunderstanding of a calendar used by the ancient Maya people. Although the Maya made no doomsday predictions, some modern individuals and groups claimed they had foretold the end on Dec. 21, 2012.

Because the doomsday predictions were largely grassroots and spread online, the fallout from their failure is likely to be more varied than in doomsdays past, said Stephen Kent, a University of Alberta sociologist. Most of the time, doomsday predictions are made by charismatic leaders, often in cultlike settings. [Tales of the 10 Craziest Cults]

"It appears that believers in the Mayan calendar apocalypse range from troubled individuals to groups following charismatic leaders," Kent told LiveScience. "Consequently, the fallout could be very complicated."

When the world won't end
After a failed doomsday, believers respond with a range of reactions, from disavowing their former apocalyptic beliefs to, surprisingly, believing more than ever. One classic reaction is the one made by Harold Camping, a radio preacher who first predicted Judgment Day in 1994. When that date didn't pan out, Camping made a common claim among doomsday prophets ? the math had been wrong, but the ultimate prophecy would still prove true. He then predicted a widely publicized Judgment Day in May 2011, which also failed to occur. After that failure, Camping claimed the Judgment Day had been "spiritual" in nature and that the world would still end in a few short months.

When that claim also failed, Camping finally admitted his error. Rationalizing and attempting to explain away failure is common among failed doomsday groups, said Lorenzo DiTommaso, a professor of religion at Concordia University in Montreal. In some cases, groups even claim that their prayers saved the world.?

The Mayan apocalypse is likely to be different, if only because the Internet is bursting with dozens of contradictory prophecies about the day, DiTommaso told LiveScience.

"There are so many different predictions ridered onto the 2012 phenomenon, everyone's going to have a different response," DiTommaso said. "And because it's not a leader or a church or a doctrine or Karl Marx forecasting what the future is going to be like, there's not going to be a leader against whom you can forecast your dissatisfaction."

Facing mortality
Doomsday believers tend to pick up and get on with their lives more successfully if they have strong networks of family and friends, Kent said. The grassroots nature of the Mayan apocalypse predictions is therefore troubling, he said.

"The isolated individuals who encounter these predictions on the Internet may be terribly alone," he said. Some may be "really quite lost" in the wake of the uneventful day.

"It's not just the usual suspects," said DiTommaso of the 2012 apocalypse believers. "Lots of people can buy into 2012 for different reasons."

Part of the reason that failed doomsdays can be so traumatic, Kent said, is that they appear to be a way that people grapple with their mortality. Believers usually think they'll survive the end, whether by being one of God's chosen people, by building an underground bunker, or by hitching a ride on a friendly UFO. If you survive the end of the world, Kent said, you never have to face your own death.

"The believers always predict that their special knowledge will allow them to survive, that they will escape the mortality that all of us face," Kent said. "And so far, everyone's been proven wrong on that fact."

However, hope springs eternal. Matching the dates of the Mayan calendar to our modern calendar is not an exact science, offering doomsday believers a "we got the math wrong" rationalization for the failed prediction.

Already, "there's a bit of chatter for 2015," DiTommaso said.

Follow Stephanie Pappas on Twitter @sipappasor LiveScience @livescience. We're also on Facebook& Google+.

? 2012 LiveScience.com. All rights reserved.

Source: http://www.msnbc.msn.com/id/50278218/ns/technology_and_science-science/

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Your Disturbing Christmas Song of the Day: Sufjan Stevens - I'll Be Home for Christmas (Little green footballs)

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Saturday, December 22, 2012

Expression of Cytochrome1b1in Human Endometrial Cancer ...

[Abstract]

Objective:Endometrial cancer is one of three gynecologic malignanttumors, including cervical cancer and ovarian cancer. In recent years, themorbidity is increasing and it seriously endangers the health of women. But itspathogenesis is not yet clear. It is believed that exposure to endogenous orexogenous estrogens, which is not opposed by progesterone, increases the riskof developing endometrial cancer. Estrogen related intracellular metabolismincludes cytochrome P4501B1(CYP1B1)-mediated oxidation (mainly for thehydroxylation) and catechol-O-methyltransferase (COMT)-mediatedmethylation. Cytochrome P4501B1(CYP1B1) is involved in estrogenmetabolism? whose metabolites are associated with the initiation andprogression of cancer. catechol-O-methyltransferase (COMT) convertsestrogen metabolites to nontoxic substances and cleans them out of body. Theaim of the study was to detect CYP1B1, COMT cell localization in cell andexpression difference between endometrial cancer and normal endometrium,then to explore the significance of both in endometrial cancer progression,then to provide a new idea to dometrial cancer etiology, diagnosis andtreatment.Methods:Total40Endometrial cancer tissues were collected aftersurgery and were confirmed by pathology in the department of Gynecologyand Obstetrics in the4th hospital of Hebei Medical Universiry.Total35normal endometrium tissues were chosen in the same area as control group(from patients of cervical carcinoma, without uterine fibroids, endometrialhyperplasia, ovarian cancer and other related gynecological diseases). Alltissues were stored in10%formalin, were made into wax block after7days.Immunohistochemistry (SP) was used to detect the expression of CYP1B1andCOMT. The Olympus DP70imaging system was used to take pictures. Stained specimens was analysised by image analysis system Image-ProPlus5.1(USA). Statistical analysis was performed using SPSS13.0softwarepackage. Comparison of two groups was performed by t-test and three groupsby the One-Way ANOVA. Comparison of two groups, with uneven variance,was performed by the non-parametric test. P<0.05was considered significantfor all statistical analysis.Results:1CYP1B1and COMT were expressed in cell plasma, few in theinterstitial and (or) glandular cell nuclear. This study was mainly to comparethe expression in the cytoplasm of glandular epithelial cell.2The age difference was not significant between the endometrial cancerpatients and healthy controls.The distribution of CYP1B1and COMTexpressions in the case and control groups were normal.3The mean optical density (OD) of CYP1B1in the case group?0.259?0.044? was significantly higher than that in control group?0.169?0.184?, the difference was statistically significant (P=0.000);While the OD of COMT in the case group ?0.208?0.058? was lower thanthat in control group, the difference was statistically significant (P=0.000).4The expression of CYP1B1were significantly different in differentstages of endometrial carcinoma (P<0.05), and the more advanced stage, thestronger the expression was. In the case group, CYP1B1expression in ERpositive group was stronger than in ER negative group. The expression ofCOMT in P53positive group was stronger than in P53negative group (P=0.035).5The expresstion of CYP1B1and COMT had positive linear correlationin the control group(r=0.384, P=0.025).Conclusions:1The expression of CYP1B1in endometrial cancer tissues was higherthan that in the normal tissues, indicating that CYP1B1may play an importantrole in the occurrence of endometrial cancer, which provide a new way ofdiagnosis, treatment and prognosis about endometrail cancer. 2With ER expression increased gradually, CYP1B1expression showeda rising trend, suggesting that CYP1B1may be regulated through ER pathway.3The expression of CYP1B1in endometrial cancer tissues was strongerthan that in the normal tissues, suggesting that CYP1B1may be used as theprognosis indicator of endometrial cancer.4The expression of COMT in control group was higher than that in thecase group, implying that COMT may play a protective role in endometrialcancer occurrence and development.5The expresstion of CYP1B1and COMT had positive linear correlationin the control group, indicating that both coordinates to maintain the normalestrogen metabolism, and to prevent excessive production of carcinogens.

Title: Expression of Cytochrome1b1in Human Endometrial Cancer Associated with ER Expression

Category: Liver Cancer

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Source: http://www.rescancer.com/liver-cancer/72745.html

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PFT: Sanchez and Tebow riding pine on Sunday

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[Editor's note:? This is my first post of the day from Amtrak's Pennsylvanian, a 9.5-hour trek from Pittsburgh to New York City.? Which is about as long as it takes to drive there and halfway back.]

If the fans have their way, Bills S Jairus Byrd will be a Pro Bowl starter.

The Patriots have plenty of connections to their upcoming opponent in Jacksonville.

With $45 million in cap space and nine draft picks, 2013 could be the year that Dolphins G.M. Jeff Ireland sinks or swims.

Like Tim Tebow, offensive coordinator Tony Sparano may be one and done with the Jets.

Browns LB D?Qwell Jackson accepts the fact that changes are coming ? again ? in Cleveland; ?Been down here, this road, a little bit,? Jackson said. ??That?s been the majority of my career, every couple of years there?s a new regime. ?It?s a bottom-line business. You?ve got to win in this business, and we all understand it.?

Ravens RB Ray Rice knows that his touches are tied to the team?s overall effectiveness on offense.

There?s still time for Steelers fans to submit their own videos explaining where they were for the Immaculate Reception. ?(Our guess is that Three Rivers Stadium, which held roughly 50,000, had a capacity of 500,000 that day.? Or more.)

When it comes to the importance of Sunday?s game at Pittsburgh, Bengals coach Marvin Lewis is pragmatic;??It?s a really big game for us and for our young players it?s a chance for them to have an opportunity to keep playing; that?s what we?re here for,? Lewis said.

A limited number of $20 tickets will be available Saturday morning for the Jaguars? home game against New England.

Titans RB Chris Johnson thinks Adrian Peterson should win the league MVP award.

The Texans will hold a silent auction to benefit the victims of the Newtown shooting.

Colts WR Reggie Wayne knows that the 2-12 Chiefs will be playing to win on Sunday, because Wayne recalls that?s what the Colts did down the stretch last year.

Original Broncos S Austin ?Goose? Gonsoulin is recovering from heart surgery and cancer and enjoying the current edition of his former team; ?I remember exactly what that feels like,? Gonsoulin said of the 98-yard interception return from CB Chris Harris.

As the Norv Turner tenure comes to a conclusion with the Chargers, Turner faces the team responsible for his most important defeat.

The bad news?? The Raiders have 17 players who will become unrestricted free agents in March.? The good news?? The Raiders have 17 players who will become unrestricted free agents in March.

Welcome to PFT Planet, Giants WR Hakeem Nicks.

When the Eagles host Washington on Sunday, RB Brian Westbrook will serve as an honorary captain.

Cowboys TE Jason Witten still has a strong relationship with his former coach, Bill Parcells.

In many statistical categories, the Redskins are either really good or really bad.

A year after having the worst defense in the league, the Packers are now in the middle of the pack.

The Bears will use their fifth different combination of offensive linemen in five games against Arizona on Sunday.

Three years ago, it was ?Pants on the Ground?; now, the Vikings are breakdancing.

For Lions LB Stephen Tulloch, the glass is still five-percent full; ?This is a great opportunity to play on national television and show the fans and the people across the country that the Lions, we?ve been down but we?re coming back heading into next season,? Tulloch said.

LB Jonathan Vilma and DE Will Smith could be cap casualties for the Saints.

Falcons LT Sam Baker, who has rebounded after a difficult 2011, hopes to remain with the team beyond the expiration of his rookie contract in March.

For Buccaneers LT Donald Penn, the secret to his success is a different sport; ?I don?t think I?d be as good of an athlete if it wasn?t for basketball,? Penn said. ?I don?t think I?d be as good of a left tackle.?

The Panthers welcome former RB Mike Goodson to town on Sunday, fresh from an 89-yard rushing day, his best performance with Oakland.

Cardinals defensive coordinator Ray Horton raved about CB Patrick Peterson; ?He could really be the Bo Jackson, the two-way player. He is a phenomenal athlete that isn?t missing anything. ?He has the smarts, the will, the desire, the heart, the drive, any adjective you want to throw in there he has.?

Seahawks WR Sidney Rice is questionable for Sunday, but coach Pete Carroll thinks he?ll play; ?We?re still going to make sure he can run on game day,? Carroll said. ?He feels pretty good right now.? But we?ve got to get to game day and run him and see how he can tolerate it.? He thinks he?s playing.? He feels like he?s going to.?

The Rams fired Mike Martz seven years ago, but this year they can?t get away from him.

As 49ers DL Ricky Jean Francois was grilled by the media about his preparedness to play in place of Justin Smith, WR Randy Moss and OL Mike Iupati joined in the questioning.

Source: http://profootballtalk.nbcsports.com/2012/12/21/sanchez-is-expected-to-be-no-2-on-sunday/related/

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Florida governor asks Obama to block possible ports strike

MIAMI (Reuters) - Florida's Republican governor wants President Barack Obama to invoke federal law and order a cooling-off period if nearly 15,000 longshoremen walk off the job in a looming strike that would be a big blow to the state's economy, according to a letter he sent the president this week.

The International Longshoremen's Association union and the U.S. Maritime Alliance grouping of shippers and ports have been bargaining since March but reportedly remain far from a deal covering cargo handling at 15 ports on the U.S. Gulf and eastern coasts.

In October, when a previous contract expired, the sides agreed to a 90-day extension of terms that runs out on December 29.

Florida ports in Miami and Fort Lauderdale would be directly hit by a strike or lockout but a stoppage would also rattle overall transport and trade, which accounts for 550,000 jobs in the state and $66 billion in economic activity, Florida Governor Rick Scott said in a letter dated Thursday.

"The threat to national safety and security that would result from mass closure of ports cannot be overstated," Scott told Obama.

Scott said Obama had the power under 1947's Taft-Hartley Act to prevent or interrupt a work stoppage at the ports. Presidents Richard Nixon and George W. Bush both used Taft-Hartley, which calls for 80-day cooling-off periods and mediation, Scott said.

"The Taft-Hartley Act provides your administration with tools that can help avoid this threat," Scott said. "On behalf of the State of Florida, I respectfully request that you invoke the act when the contract ... expires at the end of the month."

(Reporting By Michael Connor in Miami; Editing by Cynthia Johnston)

Source: http://news.yahoo.com/florida-governor-asks-obama-block-possible-ports-strike-225639458.html

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Friday, December 21, 2012

Sony VAIO Core i5 Dual 2.5GHz 14" LED Laptop for $578 + free shipping

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$578 +?free?shipping

Shop Now!Walmart offers the 5.3-lb. Sony VAIO E Series Intel Core i5 Dual Core 2.5GHz 14" LED-Backlit Widescreen Notebook in White, model no. SVE14118FXW, for $578 with free shipping. That's $152 under our July mention and the lowest total price we could find. Sales tax is added where applicable. It features an Intel Core i5-2450M 2.5GHz dual-core Sandy Bridge processor, 14" 1366x768 LED-backlit widescreen LCD, 8GB RAM, 750GB hard drive, DVD burner, 802.11n wireless, Gigabit Ethernet, webcam, media card reader, USB 3.0 port, 6-cell battery, and Windows 7 Home Premium 64-bit.

It won't arrive in time for Christmas.

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Hey Look The World Didn't End Today

Testing, testing. Anyone there? If you can see these words, you'd have survived the great 2012 Mayan Apocalypse. Congratulations! You're all still alive! It's now 12:00 AM on December 21st 2012 and everything seems to be still ticking. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/fLzXDB_eMog/hey-look-the-world-didnt-end-today

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